The heavy metals from aquatic environment can be transported, absorbed, and stored in mangrove tissues. This study aims to assess accumulations of Cu and Zn in the sediment, root and stem of Avicennia sp. as affected by human activity in Blanakan riparian, West Java. Avicennia sp. root, stem, water, and sediment samples were collected from 2 stations located in Blanakan riparian. The concentrations of Cu and Zn in samples were measured using an atomic absorption spectrophotometer (AAS). Bioconcentration factor (BCF) and translocation factor (TF) equations were used to analyse the Cu and Zn accumulations in Avicennia sp. Based on the sediment quality guidelines, the sediment samples were not polluted for Cu (2.23–2.26 mg/kg) and moderately polluted for Zn (92.83–95.86 mg/kg). Moreover, the Cu and Zn in the water have BCF values of root ranging from 257.5–295 and 97.07–390.29, while BCF values of stem ranging between 590–990 and 90.23–330.21, respectively. Furthermore, the Cu and Zn in the sediment have BCF values of root ranging from 0.23–0.26 and 0.30–0.57, while BCF values of stem ranging between 0.53–0.88 and 0.30–0.48, respectively. In addition, the TF values ranged from 2.29–3.36 for Cu and 0.85–0.93 for Zn. To summarize, the root and stem of Avicennia sp. have the ability to translocate Cu from water and sediment in Blanakan riparian.