Cadmium is a heavy metal widely used in human life. If it enters the human body, Cadmium will bind to metallothionein protein and may impair the renal function. The decrease of renal function usually is characterized by an increase of Beta-2-Microglobulin creatinine, ureum, and uric acid levels, which possibly might be cured by lycopene, an antioxidant found in tomato. The objective of this study was to determine the effective lycopene dose as renoprotective of Cd exposure. Twenty four Wistar rats were used in this study. They were divided into six groups, with four individuals in each group. Group I was the negative control, group II was given 5.6 mg/kgBW CdSO₄ as a positive control, group III, IV, and V were given 5.6 mg/kgBW CdSO₄ and tomato extract at 0.36, 0.72, and 1.08 mg/kgBW/day respectively. Group VI was given CdSO₄, and after seven days an additional 0.3 mg/kgBW/day of dimercaprol was administered for 14 days as a comparison to tomato. The parameters observed were levels of Cd, creatinine, ureum, uric acid, and Beta-2-microglobulin in blood level. Observations were made on day 0 and day 22. The data were analyzed with ANOVA (F-test) followed by Duncan test. The results showed all treatments and dimercaprol could reduce the levels of Cd, creatinine ureum, uric acid, and Beta-2-Microglobulin levels in the blood. The optimal decrease was observed in the rats administered with 1.08 mg/kgBB/day tomato extract, indicating a renoprotective effect on white rat exposed to Cd.

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